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KMID : 0370220120560020071
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Yakhak Hoeji
2012 Volume.56 No. 2 p.71 ~ p.73
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Development of an Efficient Synthetic Method for a Novel Anticancer Substance Isolated from Insect-flower
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Che Hai-Yan
Ngoc Tuyen Truong
Yoon Deok-Hyo
Kim Tae-Woong
Sung Gi-Ho
Park Hae-Il
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Abstract
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Cordyceps militaris, a caterpillar-grown traditional medicinal mushroom, produces important bioactive compounds, cordycepin (3’-deoxyadenosine) and militarin. Militarin is reported to possess anticancer activities against several tumor cells. An efficient synthetic method of militarin was developed to prepare muti-gram scale sample for bioassay. Militarin was successfully synthesized from commercial starting materials in 5 steps and 29.3% overall yields.
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KEYWORD
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Cordyceps militaris, militarin, anticancer activity, multi-gram scale
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